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教授(研究员)
李盛本
作者:   来源:    日期: 2019-03-21   浏览次数:

 


李盛本,南京农业大学表型中心教授,博士生导师。2008年于中国科学院遗传与发育生物学研究所获得博士学位,2007-2015年在美国加州大学河滨分校进行博士后研究。先后入选农业部“全国农业科研杰出人才”,科技部“中青年科技创新领军人才”和“国家万人计划领军人才”,2018年获得广东省“五一劳动奖章”, 2015年起担任中国农业科学院学术委员会委员。 

 邮箱地址:lishengben@hotmail.com

 联系方式:025-84399740

 办公地点:逸夫楼5035

 

研究领域

 

1)植物基因表达的转录后调控机制研究。鉴定植物小RNA途径的新原件,探索小RNA生物合成及调控机制;

2)农作物小分子RNA生物学功能研究。利用功能基因组学技术对农作物小RNA进行高通量系统研究;

3)玉米生长发育和重要农艺性状形成的分子机制研究。通过分子遗传学、基因组学和表型组学对影响玉米发育的关键基因进行克隆和功能研究。

 

学术成果

 

在植物小RNA生物合成及作用机制方面进行了长期的研究,发现了内质网在小RNA对靶基因进行翻译抑制过程中的作用,解析了植物内质网上小RNA的分布模式和对次级小RNA生物合成的重要作用。

 

发表文章

 

Shengben Li, Brandon Le, Xuan Ma, Shaofang Li, Chenjiang You,Yu Yu, Bailong Zhang, Lin Liu, Lei Gao, Ting Shi, Yonghui Zhao,Beixin Mo, Xiaofeng Cao, Xuemei Chen. (2016) Biogenesis of phased siRNAs on membrane-bound polysomes in Arabidopsis. eLife 5:e22750.

 

Shengben Li, Lin Liu, Xiaohong Zhuang, Yu Yu, Xigang Liu, Xia Cui, Lijuan Ji, Zhiqiang Pan, Xiaofeng Cao, Beixin Mo, Fuchun Zhang, Natasha Raikhen, Liwen Jiang, and Xuemei Chen. (2013). MicroRNAs Inhibit the Translation of Target mRNAs on the Endoplasmic Reticulum in Arabidopsis. Cell 153, 562-574.

 

Shengben Li, Qian Qian, Zhiming Fu, Dali Zeng, Xianbing Meng, Junko Kyozuka, Masahiko Maekawa, Xudong Zhu, Jian Zhang, Jiayang Li and Yonghong Wang (2009). Short panicle1 encodes a putative PTR family transporter and determines rice panicle size. The Plant Journal 58, 592-605.

 

Yihua Zhou*, Shengbe Li*, Qian Qian, Dali Zeng, Mu Zhang, Longbiao Guo, Xinfang Liu, Baocai Zhang, Lingwei Deng, Guanzheng Luo, Xiujie Wang, and Jiayang Li (2009). BC10, a DUF266- containing and Golgi-located type II membrane protein, is required for cell-wall biosynthesis in rice (Oryza sativa L.). The Plant Journal 57, 446-462. (*共同第一作者)

 

Shaofang Li, Lee E. Vandivier, Bin Tu, Lei Gao, So Youn Won, Shengben Li, Binglian Zheng, Brian D. Gregory, and Xuemei Chen (2015). Detection of Pol IV/RDR2-dependent transcripts at the genomic scale in Arabidopsis reveals features and regulation of siRNA biogenesis.Genome Research 25(2):235

 

Qian Du, Utku Avci, Shengben Li, Lina Gallego-Giraldo, Sivakumar Pattathil, Liying Qi, Michael G. Hahn andHuanzhong Wang (2015). Activation of miR165b represses AtHB15 expression and induces pith secondary wall development in Arabidopsis. The Plant Journal 83(3):388-400

 

Bin Tu, Li Liu,Chi Xu, Jixian Zhai, Shengben Li, Miguel A. Lopez, Yuanyuan Zhao, Yu Yu, Vanitharani Ramachandran, Guodong Ren, Bin Yu, Shigui Li, Blake C. Meyers, Beixin Mo, Xuemei Chen(2015).Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in 2 microRNA turnover in Arabidopsis. PLoS Genetics 11(4):e1005119

 

Shaofang Li, Lee E. Vandivier, Bin Tu, Lei Gao, So Youn Won, Shengben Li, Binglian Zheng, Brian D. Gregory, and Xuemei Chen. (2015) Detection of Pol IV/RDR2-dependent transcripts at the genomic scale in Arabidopsis reveals features and regulation of siRNA biogenesis. Genome Research 25(2):235-45.

 

James Wong, Lei Gao, Yang Yang, Jixian Zhai, Siwaret Arikit, Yu Yu, Shuyi Duan, Vicky Chan, Qin Xiong, Jun Yan, Shengben Li, Renyi Liu, Yuanchao Wang, Guiliang Tang, Blake C. Meyers, Xuemei Chen, Wenbo Ma (2014). Roles of Small RNAs in Soybean Defense against Phytophthora sojae Infection. The Plant Journal 79(6):928-40.

 

Thanh Theresa Dinh, Michael O'Leary, So Youn Won, Shengben Li, Lorena Arroyo, Xigang Liu, Andrew Defries, Binglian Zheng, Sean R Cutler, and Xuemei Chen (2013). Generation of a luciferasebased reporter for CHH and CG DNA methylation in Arabidopsis thaliana. Silence 4, 1.

 

Tzuu-fen Lee, Sai Guna Gurazada, Jixian Zhai, Shengben Li, Stacey A. Simon, Marjori Matzke, Xuemei Chen and Blake C. Meyers (2012). RNA polymerase V-dependent small RNAs in Arabidopsis originate from small, intergenic loci including most SINE repeats. Epigenetics 7, 781-795.

 

Xurong Tang, Shaomin Bian, Mingjuan Tang, Qing Lu, Shengben Li, Xigang Liu, Gang Tian, Vi Nguyen, Edward W. T.Tsang, Aiming Wang, Steven J. Rothstein, Xuemei Chen and Yuhai Cui (2012). MicroRNA-mediated repression of the seed maturation program during vegetative development in Arabidopsis. PLoS Genetics 8, e1003091.

 

So Yun Won, Shengben Li, Binglian Zheng, Yuanyuan Zhao, Dongming Li, Xin Zhao, Huila Yi, Lei Gao, Thanh Theresa Dinh, and Xuemei Chen (2012). Development of a luciferase-based reporter of transcriptional gene silencing that enables bidirectional mutant screening in Arabidopsis thaliana. Silence 3, 6.

 

Bin Yu, Liu Bi, Jixian Zhai, Manu Agarwal, Shengben Li, Qingfa Wu, Shou-wei Ding, Blake C. Meyers, Herve Vaucheret, and Xuemei Chen (2010). siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis. Nucleic Acids Research 38, 5844-5850. 14. Binglian Zheng, Zhengming Wang, Shengben Li, Bin Yu, Jinyuan Liu, and Xuemei Chen (2009). Intergenic transcription by RNA polymerase II coordinates Pol IV and Pol V in siRNA-directed transcriptional gene silencing in Arabidopsis. Genes & Development 23, 2850-2860.

 

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